2. Signaling Pathways
  3. Anti-infection
  4. Parasite

Parasite

Parasite

Related Products

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Antiparasitics are a class of medications which are indicated for the treatment of parasitic diseases such as nematodes, cestodes, trematodes, and infectious protozoa.

Parasite Isoform Specific Products:

Parasite Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N10624
    Koshidacin B
    		Inhibitor
    Koshidacin B is an antiplasmodial cyclic tetrapeptide with antiplasmodial activity against P. falciparum FCR3 and K1 strain with IC50 values of 0.89 and 0.83 μM, respectively. Koshidacin B suppresses malaria parasites in vivo, it can be used for the research of parasites infection.
    Koshidacin B
  • HY-147766
    Antileishmanial agent-10
    		Inhibitor
    Antileishmanial agent-10 (Compound 7h) is an antiprotozoal agent.
    Antileishmanial agent-10
  • HY-155024
    HAT-IN-8
    		Inhibitor
    HAT-IN-8 (Compound 38) is a BBB-penetrable T. brucei inhibitor (EC50: 0.18 μM). HAT-IN-8 can be used for the research of Human African trypanosomiasis.
    HAT-IN-8
  • HY-P11102
    Temporin-SHa
    		Inhibitor
    Temporin-Sha is an antibacterial peptide with extensive biological activity. Temporin-Sha exhibits broad-spectrum antibacterial activity (e.g., against L. ivanovii, MIC = 6.25 μM), and is effective against Gram-negative bacteria (such as Escherichia coli, MIC = 10 μM), including drug-resistant strains (such as Methicillin (HY-121544)-resistant Staphylococcus aureus). Temporin-Sha also has inhibitory effects on Candida albicans (MIC = 25 μM), Saccharomyces cerevisiae (MIC = 12 μM), the pre-flagellated and non-flagellated forms of Leishmania infantum (IC50 = 5-20 μM), and Trypanosoma cruzi (IC50 = 17 μM). Temporin-Sha exhibits antiviral activity against HSV-1 and has anti-cancer effects (cytotoxicity against breast cancer cells MCF-7 and lung cancer cells H460, etc.).
    Temporin-SHa
  • HY-17589S1
    Chloroquine-d4 phosphate
    		Inhibitor
    Chloroquine-d4 (phosphate) is the deuterium labeled Chloroquine phosphate. Chloroquine phosphate is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine phosphate is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine phosphate is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM).
    Chloroquine-d<sub>4</sub> phosphate
  • HY-126601
    Malonganenone A
    		Inhibitor
    Malonganenone A is an antimalarial marine alkaloid that disrupts the interaction between PfHsp70-x and Hsp40. Malonganenone A inhibits plasmodial and not human Hsp70 ATPase activity (Hsp40-stimulated), and hindered the aggregation suppression activity of PfHsp70-x.
    Malonganenone A
  • HY-146744
    Antileishmanial agent-4
    		Inhibitor
    Antileishmanial agent-4 is a ribonucleoside analogue and acts as an antileishmanial agent.
    Antileishmanial agent-4
  • HY-163395
    3-Tosylimidazolidine-2,4-dione
    		Inhibitor
    3-Tosylimidazolidine-2,4-dione (compound 2C) is a hydantoins derivative, and exhibits inhibitory activity against the Pf3D7 strain, with an IC50 value of 3.97  nM.
    3-Tosylimidazolidine-2,4-dione
  • HY-W012941R
    2-Thiophenecarboxaldehyde (Standard)
    		Inhibitor
    2-Thiophenecarboxaldehyde (Standard) is the analytical standard of 2-Thiophenecarboxaldehyde. This product is intended for research and analytical applications. 2-Thiophenecarboxaldehyde (Thiophene-2-carboxaldehyde) is an antibiotic that exhibits antibacterial and nematicidal activities.
    2-Thiophenecarboxaldehyde (Standard)
  • HY-126406
    Tirandamycin A
    		Inhibitor
    Tirandamycin A, an antibiotic, is a bacterial RNA polymerase inhibitor. Tirandamycin A has antiamoebic and antibacterial properties.
    Tirandamycin A
  • HY-107212R
    Selamectin (Standard)
    		Inhibitor
    Selamectin (Standard) is the analytical standard of Selamectin. This product is intended for research and analytical applications. Selamectin, a semi-synthetic macrocyclic lactone, is a potent parasiticide and anthelminthic. Selamectin activates glutamate-gated chloride channels in neurons and pharyngeal muscles to prevent heartworm, Lymphatic filariae, and nematode infection. Selamectin is also a potent P-glycoprotein substrate and a P-glycoprotein inhibitor with an IC50 of 120 nM.
    Selamectin (Standard)
  • HY-B1194A
    Tetramisole
    		Inhibitor
    Tetramisole is an orally active, selective inward rectifier potassium channel agonist with an EC50 of approximately 30 μM for the Kir2.1 subunit. Tetramisole is also an anti-nematode agent that blocks neuromuscular transmission by non-competitive depolarization. Tetramisole promotes the forward transport of Kir2.1 channels, hyperpolarizes the resting potential (RP), shortens the action potential duration (APD), inhibits intracellular calcium overload and the PKA signaling pathway, and exerts anti-arrhythmic and anti-myocardial remodeling activities. Tetramisole can be used in cardiac electrophysiology research and research related to myocardial ischemia and heart failure.
    Tetramisole
  • HY-169099
    Antiproliferative agent-56
    		Inhibitor
    Antiproliferative agent-56 (Compound 31) is an antimalarial agent, that inhibits Plasmodium falciparum 3D7 (Pf3D7) with an IC50 >12.5 (48h) and 0.03 μM (98h), and reveals a slow-acting property.
    Antiproliferative agent-56
  • HY-114197
    Antimalarial agent 14
    		Inhibitor 99.33%
    Antimalarial agent 14 (Compound N3) is a potent inhibitor of mitochondrial electron transport. Antimalarial agent 14 can serve as an anti-malarial agent.
    Antimalarial agent 14
  • HY-17595S1
    Mebendazole-d8
    		Inhibitor
    Mebendazole-d8 is the deuterium labeled Mebendazole. Mebendazole is a highly effective, broad-spectrum antihelmintic indicated for the treatment of nematode infestations; has been found as a hedgehog inhibitor.
    Mebendazole-d<sub>8</sub>
  • HY-163003
    Antitrypanosomal agent 19
    		Inhibitor
    Antitrypanosomal agent 19 (compound 10) is an orally available antitrypanosomal agent. Antitrypanosomal agent 19 effectively inhibits the growth of trypanosomatids T. b. brucei, T. b. gambiense and T. b. rhodesiense, mitigating the Human trypanosomiasis (HAT)-induced acute infectious toxicity in mice.
    Antitrypanosomal agent 19
  • HY-B2098A
    Lucanthone hydrochloride
    Lucanthone hydrochloride is an endonuclease inhibitor of Apurinic endonuclease-1 (APE-1).
    Lucanthone hydrochloride
  • HY-156063A
    (2R,4R)-UCB7362 hydrochloride
    		Inhibitor
    (2R,4R)-UCB7362 hydrochloride is the (2R,4R) isomer of UCB7362 (HY-151568). (2R,4R)-UCB7362 hydrochloride is an inhibitor of plasma proteinase X (PMX) with antimalarial activity.
    (2R,4R)-UCB7362 hydrochloride
  • HY-126295
    Anti-parasitic agent 3
    		Inhibitor
    Anti-parasitic agent 3 is an anti-parasitic agent which active against agent resistant parasites.
    Anti-parasitic agent 3
  • HY-113050SA
    2,3-Diphosphoglyceric acid-d3 ammonium
    		Inhibitor
    2,3-Diphosphoglyceric acid-d3 ammonium (2,3-DPG-d3 ammonium) is the deuterium labeled 2,3-Diphosphoglyceric acid (HY-113050). 2,3-Diphosphoglyceric acid (2,3-DPG) is an intermediate of the glycolytic pathway. 2,3-Diphosphoglyceric acid stabilizes the deoxygenated form of hemoglobin by allosteric binding and facilitates oxygen release at tissue sites. 2, 3-diphosphoglyceric acid has antiparasitic activity. 2,3-Diphosphoglyceric acid can be used in the study of Alzheimer's disease (AD).
    2,3-Diphosphoglyceric acid-d<sub>3</sub> ammonium
Parasite Isoform Comparison

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